Hem Shukla, PhD
- Personal Statement
After completing my PhD, I have been involved in investigating the role of heat shock proteins and chaperones under stress conditions with main emphasis on carcinogenic heavy metals, and mechanism of cell survival. During my postdoctoral training, I mainly focused on genomics, and systems biology approaches to understand mechanisms of cellular homeostasis and survival under stress. I have extensive experience in cell biology with a focus on identifying biomarkers for preclinical and clinical research against pancreatic and small cell lung cancer. Later, I joined National Institute on Aging, NIH and focused my research efforts on pancreatic cancer signaling and cancer biomarker discovery for early detection. Further, I joined Department of Biology and Institute of Cell Engineering at Johns Hopkins University School of Medicine and worked on role of interferon regulatory factor 3 (IRF3) and ubiquitin-proteasome pathway in pancreatic cancer. Currently, the focus of my lab is also to understand the role of Proton and FLASH radiation in treating locally advanced pancreatic cancer (LAPC) using tumor organoid culture and develop effective therapeutic options. My lab has been successful in developing pancreatic tumor organoids from patient’s tumor tissue and adjacent healthy tissues and use the tumor organoids as clinical tools to understand pancreatic cancer patients’ response to radiation and chemotherapy. My research has been published in peer-reviewed high-impact journals, including PNAS, Frontiers in Oncology, Cancer Research, Cancer Letters, Cancers.
Disclosures:
- Employment: none
- Compensation: none
- Ownership: none
- Leadership: none